Peripheral Neuropathy Sciatica


Peripheral neuropathy sciatica is classified as a pseudo-sciatica that mimics traditional sciatic nerve pain traveling down the lower back into both legs and down to the feet. This pain may be intermittent in the beginning but is known to progress to a chronic state. Pain treatment will be the same course as peripheral neuropathy. While true sciatica occurs from problems arising from the compression of the nerve root source of the sciatic nerve, peripheral neuropathy pseudo-sciatica stems from the smaller nerves which branch out throughout the body into the lower extremities. These nerves control the motor and sensory needs.

Treating Your Pain

Over-the-counter pain relievers like nonsteroidal anti-inflammatory drugs are helpful with early pain. Capsaicin-based creams may provide temporary relief; however, not everyone can use these creams without skin irritation. Daily massaging of the lower back and leg area with arnica oil has shown good temporary pain relief results.

When Over-The-Counter Is Not Enough

Eventually, chronic pain will progress to the point of being unbearable. You should consult your physician or pain clinic about the possibility of prescription medications. Superficial Siderosis patients often need to begin a pain regimen of multiple medications until a combination is found that will work for you.

  • Anti-convulsant medications*
    • gabapentin (Gralise, Neurontin)
    • pregabalin (Lyrica), developed to treat epilepsy, may relieve nerve pain.

 *Side effects can include drowsiness and dizziness.

  • Antidepressants (some tricyclic antidepressants)
    • amitriptyline
    • doxepin
    • nortriptyline (Pamelor)


Please Note: These prescription pain medications are suggestions that Superficial Siderosis patients have reported some success in controlling pain. is not a physician or medical professional and so cannot endorse a specific treatment. Please consult with your personal physician or pain clinic before beginning any suggested regimen.





Updated November 5, 2020

Sources: Superficial siderosis is a rare neurologic disease characterized by progressive sensorineural hearing loss, cerebellar ataxia, pyramidal signs, and neuroimaging findings revealing hemosiderin deposits in the spinal and cranial leptomeninges and subpial layer. The disease progresses slowly, and patients may present with mild cognitive impairment, nystagmus, dysmetria, spasticity, dysdiadochokinesia, dysarthria, hyperreflexia, and Babinski signs. Additional features reported include dementia, urinary incontinence, anosmia, ageusia, and anisocoria. Superficial siderosis MedGen UID: 831707 •Concept ID: CN226971 •Finding Orphanet: ORPHA247245
Living With SuperficialSiderosis Website PubMed Reference Library 

About Living With Superficial Siderosis

Living with Superficial Siderosis is the informational

Comments are closed.