Symptoms And Signs
Symptom Glossary
Superficial Siderosis of the Central Nervous System (iSS)
A reference resource offering a brief description of recognized or associated symptoms of superficial siderosis of the central nervous system.
It is important to remember that no patient will develop every symptom. The location and volume of each individual’s hemosiderin play an important role in their personal progression.
Hearing
95% will develop progressive hearing
loss in both ears
MYELOPATHY
76% will experience spinal cord and
nerve dysfunction.
- Bowel Function
- Hyperreflexia
- Myelopathy
- Nerve Palsies
- Peripheral Neuropathy
- Peripheral Neuropathy Sciatica
- Sensory Impairment
- Sexual Dysfunction (Female)
- Sexual Dysfunction (Male)
- Spasticity
- Urinary Problems
Cognitive
A study of the largest cohort to date revealed cognitive impairment is a common sign of superficial siderosis and is related to the progression stage of the disorder.
- Dementia
- Mild Cognitive Impairment
- Short Term Memory Loss
- Executive Thought Dysfunction*
- Mood Disorder*
- Visual Recognition Memory*
- Neuropsychological Disturbance*
- *Newly Confirmed- definitions coming
Ataxia
88% will experience signs of gradual
wide-based gait, balance, and mobility
issues
- Anisocoria
- Anosmia
- Ataxia
- Cerebellar Dysarthria
- Chronic Fatigue
- Dementia
- Diplopia (Double Vision)
- Dysdiadochokinesia (DDK)
- Dysphagia
- Mild Cognitive Impairment
- Motor Skills Impairment
- Nystagmus
- Phantosmia
- Short Term Memory Loss
- Wide Based Gait
