Vestibular function in superficial siderosis

Vestibular deficits due to SS have rarely been reported
in the otolaryngological literature because early reports
noted the selective deposition of hemosiderin around
the CNS and/or the 8th nerve in contact with the
cerebrospinal fluid, most notably the cerebellum, brainstem,
lining of the ventricles, and spinal cord [1,4].
These deposits around CNS structures and/or the 8th
nerve were considered to be the changes most responsible
for the disequilibrium of SS.

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Effects of acetyl-DL-leucine in patients with cerebellar ataxia

No existing medication has yet been shown to
convincingly improve cerebellar ataxia. Therefore, the
identification of new drugs for its symptomatic treatment is
desirable. The objective of this case series was to evaluate
the efficacy of treatment of cerebellar ataxia with the
amino acid acetyl-DL-leucine (Tanganil). Thirteen patients
(eight males, median age 51 years) with degenerative
cerebellar ataxia of different etiologies (SCA1/2, ADCA,
AOA, SAOA) were treated with acetyl-DL-leucine (5 g/
day) without titration for 1 week.

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Cognitive and social impairments in patients with superficial siderosis

Superficial siderosis of the CNS is a rare condition, caused
by deposition of haemosiderin in the superficial layers
of the CNS due to repeated chronic subarachnoid or intraventricular
hemorrhage. Typically, the hindbrain structures,
especially the cerebellum, are most affected. There
is a surprising lack of studies investigating in detail the
behavioral functioning of patients with such a condition.
In this study, we document for the first time the cognitive,
social and emotional processing of six patients with a
confirmed clinical diagnosis of superficial siderosis.

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Cochlear Implant Patients with Superficial Siderosis Mayo Clinic

It is essential that the CI audiologist not only be aware of the disorder but also be well
versed in the resulting implications for the cochlear implant process. A more thorough case history, an
expanded candidacy test battery, and knowledge of the typical presentation of SSCN are critical. The
diagnosis of SSCN will impact expectations for success with the cochlear implant, and counseling
should be adjusted accordingly. Mayo Clinic Arizona, Scottsdale; {Mayo Clinic Rochester, Rochester, MN

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Anti-Inflammatory Properties of Arnica

In traditional medicine, alcoholic preparations from flowers
of Arnica montana and Arnica chamissonis ssp. foliosa are
applied externally to treat hematomas, contusions, sprains,
rheumatic diseases, and superficial inflammations of the skin.
The secondary metabolites that mediate the anti-inflammatory
effects are sesquiterpene lactones of the 10a-methylpseudoguaianolide
type like helenalin, 11a,13-dihydrohelenalin, chamissonolid,
and their ester derivatives (1–3). Several studies have
investigated how these natural compounds exert their antiinflammatory
effect.

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The Antinociceptive Properties of the Corydalis yanhusuo Extract

Corydalis yanhusuo.W.T. extracts (YHS) are widely used for the treatment of pain and
inflammation. There are a few studies that assessed the effects of YHS in pain assays; however,
none of these studies has systematically compared its activities in the different pain
animal modes namely: acute, inflammatory and chronic pain. Furthermore, little is known
about the mechanism of YHS activity in these assays. The aim of this study was to systematically
evaluate the antinociceptive properties of YHS by testing it in four standardized pain
assays and to investigate its mechanism. YHS antinociceptive properties were analyzed in
the tail flick, the formalin paw licking, the von Frey filament and the hot box assays after spinal
nerve ligation, which monitors acute nociceptive, persistent inflammatory and chronic
neuropathic pain, respectively.

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