- Version 1.0
- Download 95
- File Size 1.66 MB
- File Count 1
- Create Date October 20, 2021
- Last Updated October 20, 2021
Quantitative clinical and radiological recovery in post-operative
patients with superficial siderosis by an iron chelator
Yurie Nose · Ikuko Uwano · Ukihide Tateishi · Makoto Sasaki · Takanori Yokota · Nobuo Sanjo Oct.2021
"Results Significant improvements in signal contrast ratios were noted in the lateral orbitofrontal gyrus, superior temporal
lobe, insular lobe, brainstem, lingual gyrus, and cerebellar lobe in the combination therapy group. The scores of patients in
the combination therapy group on the cerebellar ataxia scales significantly improved. The degree of signal improvement in
the cerebellar lobe correlated with the improvement of cerebellar ataxia scores. Early deferiprone administration after disease
onset and long-term administration were correlated with greater signal improvements on magnetic resonance imaging. No
adverse effects were observed in the clinical or laboratory parameters.
Conclusions Deferiprone administration significantly improved radiological and clinical outcomes in patients with postoperative superficial siderosis. Earlier and longer courses of deferiprone could result in better patient prognosis."