Anti-Inflammatory Properties of Arnica

Arnica montana   Köhler–s Medizinal Pflanzen 015

In traditional medicine, alcoholic preparations from flowers
of Arnica montana and Arnica chamissonis ssp. foliosa are
applied externally to treat hematomas, contusions, sprains,
rheumatic diseases, and superficial inflammations of the skin.
The secondary metabolites that mediate the anti-inflammatory
effects are sesquiterpene lactones of the 10a-methylpseudoguaianolide
type like helenalin, 11a,13-dihydrohelenalin, chamissonolid,
and their ester derivatives (1–3). Several studies have
investigated how these natural compounds exert their antiinflammatory

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The Antinociceptive Properties of the Corydalis yanhusuo Extract

Corydalis yanhusuo.W.T. extracts (YHS) are widely used for the treatment of pain and
inflammation. There are a few studies that assessed the effects of YHS in pain assays; however,
none of these studies has systematically compared its activities in the different pain
animal modes namely: acute, inflammatory and chronic pain. Furthermore, little is known
about the mechanism of YHS activity in these assays. The aim of this study was to systematically
evaluate the antinociceptive properties of YHS by testing it in four standardized pain
assays and to investigate its mechanism. YHS antinociceptive properties were analyzed in
the tail flick, the formalin paw licking, the von Frey filament and the hot box assays after spinal
nerve ligation, which monitors acute nociceptive, persistent inflammatory and chronic
neuropathic pain, respectively.

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DHCB Corydalis yanhusuo

A Novel Analgesic Isolated from a Traditional Chinese Medicine •DHCB is isolated from C. yanhusuo, a plant used for centuries for pain relief •DHCB is antinociceptive against acute, inflammatory, and neuropathic pains •DHCB’s antinociception relies on its inhibitory activity at the dopamine D2 receptor •DHCB administration does not induce antinociceptive tolerance

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