In traditional medicine, alcoholic preparations from flowers of Arnica montana and Arnica chamissonis ssp. foliosa are applied externally to treat hematomas, contusions, sprains, rheumatic diseases, and superficial inflammations of the skin. The secondary metabolites that mediate the anti-inflammatory effects are sesquiterpene lactones of the 10a-methylpseudoguaianolide type like helenalin, 11a,13-dihydrohelenalin, chamissonolid, and their ester derivatives (1–3). Several studies have investigated how these natural compounds exert their antiinflammatory effect.
Category: Pain Management
Corydalis yanhusuo.W.T. extracts (YHS) are widely used for the treatment of pain and inflammation. There are a few studies that assessed the effects of YHS in pain assays; however, none of these studies has systematically compared its activities in the different pain animal modes namely: acute, inflammatory and chronic pain. Furthermore, little is known about the mechanism of YHS activity in these assays. The aim of this study was to systematically evaluate the antinociceptive properties of YHS by testing it in four standardized pain assays and to investigate its mechanism. YHS antinociceptive properties were analyzed in the tail flick, the formalin paw licking, the von Frey filament and the hot box assays after spinal nerve ligation, which monitors acute nociceptive, persistent inflammatory and chronic neuropathic pain, respectively.
A Novel Analgesic Isolated from a Traditional Chinese Medicine •DHCB is isolated from C. yanhusuo, a plant used for centuries for pain relief •DHCB is antinociceptive against acute, inflammatory, and neuropathic...